Author – Communicable Diseases Research

Diltiazem inhibits SARS-CoV-2 cell attachment and internalization and decreases the viral infection in mouse lung

Diltiazem은 SARS-CoV-2 세포 부착 및 내재화를 억제하고 마우스 폐의 바이러스 감염을 감소시킵니다

Research Article

Published on 2022-02-172022-09-10
Journal: PLoS Pathogens
[Category] COVID19(2023년), MERS, SARS, 변종,

Predicted impact of the viral mutational landscape on the cytotoxic response against SARS-CoV-2

SARS-COV-2에 대한 세포 독성 반응에 대한 바이러스 돌연변이 풍경의 영향 예측 된 영향

Research Article

Published on 2022-02-102022-09-10
Journal: PLoS Computational Biology
[Category] COVID19(2023년), Fulltext, MERS, SARS, 변종,

[키워드] accumulation adaptive affected affecting Algorithm allele Allele families allele family alleles antibodies Asian Author C-terminal change changes in Cluster complexity country COVID-19 susceptibility Critical Cytotoxic T cell deletions eight epitope Epitopes escape escape mutation event except for extreme facilitated genetic background genetic variability genetics Genome genomic HLA class I human allele human population humans immune evasion immune response independent information integration involved isolate isolates Ligand ligands local outbreaks Mutation mutations NCBI Neutralizing occurred pandemic Pandemics Population predicted Prevent Primary infection Protective proteome protocol reduction Region SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 proteome selective subpopulations Substitution Support surpassed Surveillance susceptible T cell T cell response the SARS-CoV-2 unlikely Variability variant variants Viral viral genome viral genomes viral mutation Viral mutations viral variant virus
[DOI] 10.1371/journal.pcbi.1009726 PMC 바로가기 [Article Type] Research Article

Extended ensemble simulations of a SARS-CoV-2 nsp1–5’-UTR complex

SARS-COV-2 NSP1–5'-UTR 복합체의 확장 된 앙상블 시뮬레이션

Research Article

Published on 2022-01-192022-09-10
Journal: PLoS Computational Biology
[Category] SARS, 유전자 메커니즘,

[키워드] 5’-untranslated region acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analysis Analysis Author bind binding block C-terminal causative pathogen characteristic cluster analysis complex Consistency coronavirus COVID-19 cryo cryo-EM Efficiency electron density ENCODE evade experimental evidence experiments Extended flexible Host host cells host immunity host mRNA human cell increase infected cells interactions intrinsically investigated involved mechanism modulate molecular dynamics Molecular dynamics simulation molecular mechanism mutant N-terminal nonstructural protein 1 nsp1 open pandemic of COVID-19 performed predicted Protein Recognition recognize reported residue residues respiratory ribosome RNA SARS-CoV-1 SARS-CoV-2 SARS-CoV-2-infected cells selective severe acute respiratory syndrome Coronavirus Simulation solvent suggested the SARS-CoV-2 translate translation Viral Viral RNA virus X-ray crystallographic structure
[DOI] 10.1371/journal.pcbi.1009804 PMC 바로가기 [Article Type] Research Article

SARS-CoV-2 variants with reduced infectivity and varied sensitivity to the BNT162b2 vaccine are developed during the course of infection

감염성이 감소하고 BNT162B2 백신에 대한 감도가 다양한 SARS-COV-2 변이체가 감염 과정에서 개발됩니다.

Clinical Trial

Published on 2022-01-122022-08-13
Journal: PLoS Pathogens
[Category] Biochemistry, 변종, 임상, 치료기술, 치료법,

[키워드] addition Affect Analysis analyzed Anti-spike Antibody neutralization antibody neutralization activity Author BNT162b2 BNT162b2 vaccine circulating convalescent plasma Course COVID-19 vaccine COVID-19 vaccines demonstrated elicit employment Evolution Frequency highlight Host human host human population impair in-depth analysis increase in individual infected individual infected individuals Infection infectivity capacity intra-host SARS-CoV-2 variant intra-host SARS-CoV-2 variants Intra-host variant intra-host variants L1197I mutation landscape less low frequencies mRNA mRNA-based mutated mutated variant mutated variants N gene N genes natural infection neutralization Neutralizing antibodies nose-throat swab nose-throat swabs pandemic plasma plasma neutralization activity platform Point mutation potential circulating variants Protective Quasispecies quasispecy raised reduced respiratory Respiratory system S gene S2 subunit SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 intra-host variability SARS-CoV-2 intra-host variant SARS-CoV-2 intra-host variants SARS-CoV-2 mutagenesis SARS-CoV-2 variant SARS-CoV-2 variants sensitivity Sequencing Sequencing database Sequencing databases single-genome sequencing Spike protein Spike proteins spike variant Spread swab sample swab samples the SARS-CoV-2 the spike protein vaccinated individuals vaccination rate variant variants variants of concern
[DOI] 10.1371/journal.ppat.1010242 PMC 바로가기 [Article Type] Clinical Trial

NSAIDs/nitazoxanide/azithromycin repurposed for COVID-19: potential mitigation of the cytokine storm interleukin-6 amplifier via immunomodulatory effects

NSAIDS/NITAZOXANIDE/AZITHROMYCIN COVID-19에 대한 용도 변경 : 면역 조절 효과를 통한 사이토 카인 폭풍 인터루킨 -6 앰프의 잠재적 완화

Article

Published on 2022-01-012022-08-31
Journal: Expert review of anti-infective therapy
[Category] MERS, SARS, 신약개발,

[키워드] Anti-inflammatory approach Area Aspirin Author Azithromycin benefit best Clinical studies clinical trials clinically Colchicine Combination Complication correlated COVID-19 COVID-19 complication COVID-19 complications COVID-19 pathogenesis COVID-19 patient COVID-19 patients Cytokines demonstrated Diclofenac double blind drug dysregulated dysrhythmia Effect expert Genetic ibuprofen IL-6 IL-6 amplifier Immunity immunological immunomodulatory effect immunomodulatory properties Inflammation Inflammatory response Inflammatory responses interferon interferon response interferons interleukin-6 low-dose management mediator mediators monocytic immunological dysrhythmia Mortality NF-kB nitazoxanide nitazoxanide. Non-steroidal anti-inflammatory drugs NSAIDS observational study Paracetamol positive Prevent randomized clinical trials researcher selected suggested survival the cytokine storm
[DOI] 10.1080/14787210.2021.1939683 PMC 바로가기 [Article Type] Article

Cross-reactive and mono-reactive SARS-CoV-2 CD4+ T cells in prepandemic and COVID-19 convalescent individuals

전염병 및 COVID-19 회복기 개인의 교차 반응성 및 단일 반응성 SARS-CoV-2 CD4+ T 세포

Research Article

Published on 2021-12-292022-09-10
Journal: PLoS Pathogens
[Category] SARS, 치료기술, 치료법,

[키워드] Activation allele Amino acid amino acid sequence Amino acid sequences analysis assays Author CD4+ T cell class common cold common cold coronavirus common cold Coronaviruses common cold virus common cold viruses contributed convalescent convalescent individual convalescent individuals coronavirus coronavirus COVID-19 cross-react cross-reactive cross-reactivity defined demonstrated Direct dominant epitope DPB1 elicit elicited Endemic epitope Epitopes Ex vivo frequencies Frequency functional HLA-DP HLA-DR identify immunodominant low frequency marker membrane MHC-II naïve individuals nucleocapsid Nucleocapsid proteins overlapping PBMC peptide peptides Potential prevalent Previous studies previous study proportion protective immunity Protein reactive reagent recognizing SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-CoV-2 epitope SARS-CoV-2 epitopes sequence identity shown spike staining stratified subjects suggested T cell T cell epitope T cell epitopes T cell response T cell responses T cells the Spike to define unlikely viruses was used were used world population
[DOI] 10.1371/journal.ppat.1010203 PMC 바로가기 [Article Type] Research Article

Spatially distributed infection increases viral load in a computational model of SARS-CoV-2 lung infection

공간적으로 분포된 감염은 SARS-CoV-2 폐 감염의 계산 모델에서 바이러스 부하를 증가시킵니다.

Research Article

Published on 2021-12-232022-09-12
Journal: PLoS Computational Biology
[Category] SARS, 진단,

[키워드] Affect airway Airway structure Author cells declines differential equation epithelial cells explained explicit faster immune cells immune response IMPROVE in vivo increase individuals Infection initial interactions lung lung cell lung cells Lung infection Lungs magnitude mathematical Model outcome Patient patients persist provide question replicate respiratory epithelial cell respiratory epithelial cells SARS-CoV-2 SARS-COV-2 infection Spread strength T cell T cell response T cells the timing trajectory viral growth Viral load viral loads viral persistence viral spread virus virus spread
[DOI] 10.1371/journal.pcbi.1009735 PMC 바로가기 [Article Type] Research Article

Reduced neutralisation of the Delta (B.1.617.2) SARS-CoV-2 variant of concern following vaccination

델타의 중화 감소 (B.1.617.2) 예방 접종 후 SARS-COV-2 우려 변형

Research Article

Published on 2021-12-022022-08-13
Journal: PLoS Pathogens
[Category] Biochemistry, SARS, 변종, 진단,

[키워드] (Beta accumulation African antibody Antibody titre antigenic antigenic drift antigenic profiles assessment Astra Zeneca Author B.1.351 B.1.617.1 B.1.617.2 bat bats Beta BNT162b2 BNT162b2 vaccines Booster vaccine booster vaccines ChAdOx1 changes in collected COVID-19 COVID19 death decrease decreases Delta delta variant dose effective Effectiveness Efficacy elicited evade expressed facilitate fold Fold changes glycoprotein groups hospitalisation Human human cell human cells humans Immunity India indicated individual Infection Lineage magnitude Mutation neutralisation neutralise Neutralising Antibodies neutralising antibody titres of BNT162b2 Pfizer Pfizer/BioNTech Prevent profile protective immune response pseudoviruses recipient recipients reduced reduction reduction in reductions reductions in required risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 virus sensitivity sera Severe infection shape significantly higher South South Africa spike glycoprotein spike glycoproteins Spike protein subsequent the spike protein titre vaccinated individuals vaccination Vaccine vaccine efficacy Vaccines variant variant B.1.617.2 variants variants of concern Viral viral variant Viral variants virus Virus spike VOCs while with infection with infections Wuhan Wuhan, China
[DOI] 10.1371/journal.ppat.1010022 PMC 바로가기 [Article Type] Research Article

Knowledge Update on the Economic Evaluation of Pacemaker Telemonitoring Systems

심박 조율기 원격 모니터링 시스템의 경제성 평가에 대한 지식 업데이트

Review

Published on 2021-11-182022-09-10
Journal: International Journal of Environmental Research an
[Category] MERS, SARS, 치료기술,

[키워드] absence accelerated addition age Analysis applied Atrioventricular block Author cardiovascular event Cardiovascular events Characteristics coded Complete Cost-benefit analysis COVID-19 pandemic database effective Effectiveness enrolled follow-up studies Formal Google Scholar growth Health health-related quality of life healthcare worker Healthcare workers healthy hospital implantation inclusion criteria increasingly knowledge language life long term measurement medium Methodological quality MOST no significant difference no significant differences outcomes pacemaker pacemakers Patient patients performed physical contact presence or absence primary endpoints problems Quality of life randomized clinical trials reduced reduction in reliability remote telemonitoring Sample size searched Secondary endpoints Sex significantly study duration System systematic review Telemedicine treated variable without affecting
[DOI] 10.3390/ijerph182212120 PMC 바로가기 [Article Type] Review

Universal risk phenotype of US counties for flu-like transmission to improve county-specific COVID-19 incidence forecasts

카운티 별 Covid-19 발병 예측을 개선하기위한 독감 유사 전송을위한 미국 카운티의 보편적 위험 표현형

Research Article

Published on 2021-10-142022-09-10
Journal: PLoS Computational Biology
[Category] MERS, 유전자 메커니즘,

[키워드] Applying Author automatically Behavior caused communicable communicable disease complex Course COVID-19 COVID-19 incidence COVID-19 pandemic demonstrated diagnostic disease dominant Effect Epidemic Epidemics Factor Factors flu Host identify illnesses Impact impacted IMPROVE incidence increase Infectious disease Infectious diseases Influenza influenza-like illnesses key factor knowledge Local machine learning mechanism mechanisms modulated Mortality Pandemics past pathogen Pathogens phenotype Predictive provided reduce risk seasonal flu Seasonal influenza sense Spread Transmission Universal while
[DOI] 10.1371/journal.pcbi.1009363 PMC 바로가기 [Article Type] Research Article